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- Title
OC16.03: *Improving early detection of facial clefts using first trimester sonographic markers: diagnostic accuracy based on 389,000 examinations.
- Authors
Karim, J.; Di Mascio, D.; Roberts, N.; Papageorghiou, A.
- Abstract
This article, titled "Improving early detection of facial clefts using first trimester sonographic markers: diagnostic accuracy based on 389,000 examinations," aims to determine the diagnostic accuracy of first trimester ultrasound for detecting facial clefts (FC) and the role of sonographic markers in improving screening performance. The study analyzed data from studies conducted between January 2008 and August 2022, involving 389,369 fetuses, of which 392 were affected by FC. The overall detection rate was 43.4%, with a specificity of 100.0% and a positive predictive value of 84.2%. The study suggests that accurate detection of FCs in the first trimester is feasible and can be optimized by evaluating multiple views of the fetal face with the support of sonographic markers. However, implementing such protocols requires skilled sonographers, knowledge of fetal anatomy, and additional screening time.
- Subjects
CLEFT lip; CLEFT palate; SCREEN time; FETAL anatomy; IMAGE analysis
- Publication
Ultrasound in Obstetrics & Gynecology, 2024, Vol 64, p41
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1002/uog.27831