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- Title
Chromosomal instability: a key driver in glioma pathogenesis and progression.
- Authors
Mazzoleni, Adele; Awuah, Wireko Andrew; Sanker, Vivek; Bharadwaj, Hareesha Rishab; Aderinto, Nicholas; Tan, Joecelyn Kirani; Huang, Helen Ye Rim; Poornaselvan, Jeisun; Shah, Muhammad Hamza; Atallah, Oday; Tawfik, Aya; Elmanzalawi, Mohamed Elsayed Abdelmeguid Elsayed; Ghozlan, Sama Hesham; Abdul-Rahman, Toufik; Moyondafoluwa, Jeremiah Adepoju; Alexiou, Athanasios; Papadakis, Marios
- Abstract
Chromosomal instability (CIN) is a pivotal factor in gliomas, contributing to their complexity, progression, and therapeutic challenges. CIN, characterized by frequent genomic alterations during mitosis, leads to genetic abnormalities and impacts cellular functions. This instability results from various factors, including replication errors and toxic compounds. While CIN's role is well documented in cancers like ovarian cancer, its implications for gliomas are increasingly recognized. CIN influences glioma progression by affecting key oncological pathways, such as tumor suppressor genes (e.g., TP53), oncogenes (e.g., EGFR), and DNA repair mechanisms. It drives tumor evolution, promotes inflammatory signaling, and affects immune interactions, potentially leading to poor clinical outcomes and treatment resistance. This review examines CIN's impact on gliomas through a narrative approach, analyzing data from PubMed/Medline, EMBASE, the Cochrane Library, and Scopus. It highlights CIN's role across glioma subtypes, from adult glioblastomas and astrocytomas to pediatric oligodendrogliomas and astrocytomas. Key findings include CIN's effect on tumor heterogeneity and its potential as a biomarker for early detection and monitoring. Emerging therapies targeting CIN, such as those modulating tumor mutation burden and DNA damage response pathways, show promise but face challenges. The review underscores the need for integrated therapeutic strategies and improved bioinformatics tools like CINdex to advance understanding and treatment of gliomas. Future research should focus on combining CIN-targeted therapies with immune modulation and personalized medicine to enhance patient outcomes.
- Subjects
DNA repair; TUMOR suppressor genes; MOLECULAR genetics; ASTROCYTOMAS; GLIOMAS
- Publication
European Journal of Medical Research, 2024, Vol 29, Issue 1, p1
- ISSN
0949-2321
- Publication type
Article
- DOI
10.1186/s40001-024-02043-8