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- Title
Lipidomics by Nuclear Magnetic Resonance Spectroscopy and Liquid Chromatography–High-Resolution Mass Spectrometry in Osteosarcoma: A Pilot Study.
- Authors
Pontes, João Guilherme de Moraes; Jadranin, Milka; Assalin, Márcia Regina; Quintero Escobar, Melissa; Stanisic, Danijela; Costa, Tássia Brena Barroso Carneiro; van Helvoort Lengert, André; Boldrini, Érica; Morini da Silva, Sandra Regina; Vidal, Daniel Onofre; Liu, Leticia Huan Bacellar; Maschietto, Mariana; Tasic, Ljubica
- Abstract
Cancer is a complex disease that can also affect the younger population; however, it is responsible for a relatively high mortality rate of children and youth, especially in low- and middle-income countries (LMICs). Besides that, lipidomic studies in this age range are scarce. Therefore, we analyzed blood serum samples from young patients (12 to 35 years) with bone sarcoma (osteosarcoma) and compared their lipidomics to the ones from the control group of samples, named healthy control (HC group), using NMR and LC-MS techniques. Furthermore, differences in the lipidomic profiles between OS patients with and without metastasis indicate higher glycerophosphocholine (GPC) and glycerophospholipid (GPL) levels in osteosarcoma and increased cholesterol, choline, polyunsaturated fatty acids (PUFAs), and glycerols during the metastasis. These differences, detected in the peripheral blood, could be used as biomarkers for liquid biopsy.
- Subjects
UNSATURATED fatty acids; OSTEOSARCOMA; MASS spectrometry; LIPIDOMICS; MIDDLE-income countries; CHOLINE; NUCLEAR magnetic resonance spectroscopy
- Publication
Metabolites (2218-1989), 2024, Vol 14, Issue 8, p416
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo14080416