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- Title
Endothelial Cell Dysfunction Due to Molecules Secreted by Macrophages in Sepsis.
- Authors
He, Heng; Zhang, Wei; Jiang, Luofeng; Tong, Xirui; Zheng, Yongjun; Xia, Zhaofan
- Abstract
Sepsis is recognized as a syndrome of systemic inflammatory reaction induced by dysregulation of the body's immunity against infection. The multiple organ dysfunction associated with sepsis is a serious threat to the patient's life. Endothelial cell dysfunction has been extensively studied in sepsis. However, the role of macrophages in sepsis is not well understood and the intrinsic link between the two cells has not been elucidated. Macrophages are first-line cells of the immune response, whereas endothelial cells are a class of cells that are highly altered in function and morphology. In sepsis, various cytokines secreted by macrophages and endothelial cell dysfunction are inextricably linked. Therefore, investigating how macrophages affect endothelial cells could offer a theoretical foundation for the treatment of sepsis. This review links molecules (TNF-α, CCL2, ROS, VEGF, MMP-9, and NO) secreted by macrophages under inflammatory conditions to endothelial cell dysfunction (adhesion, permeability, and coagulability), refining the pathophysiologic mechanisms of sepsis. At the same time, multiple approaches (a variety of miRNA and medicines) regulating macrophage polarization are also summarized, providing new insights into reversing endothelial cell dysfunction and improving the outcome of sepsis treatment.
- Subjects
ENDOTHELIAL cells; ENDOTHELIUM diseases; TISSUE adhesions; SEPSIS; IMMUNE response
- Publication
Biomolecules (2218-273X), 2024, Vol 14, Issue 8, p980
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom14080980