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- Title
Prenatal vitamin D deficiency exposure leads to long-term changes in immune cell proportions.
- Authors
Ueda, Koki; Chin, Shu Shien; Sato, Noriko; Nishikawa, Miyu; Yasuda, Kaori; Miyasaka, Naoyuki; Bera, Betelehem Solomon; Chorro, Laurent; Doña-Termine, Reanna; Koba, Wade R.; Reynolds, David; Steidl, Ulrich G.; Lauvau, Gregoire; Greally, John M.; Suzuki, Masako
- Abstract
Vitamin D deficiency is a common deficiency worldwide, particularly among women of reproductive age. During pregnancy, it increases the risk of immune-related diseases in offspring later in life. However, how the body remembers exposure to an adverse environment during development is poorly understood. Herein, we explore the effects of prenatal vitamin D deficiency on immune cell proportions in offspring using vitamin D deficient mice established by dietary manipulation. We found that prenatal vitamin D deficiency alters immune cell proportions in offspring by changing the transcriptional properties of genes downstream of vitamin D receptor signaling in hematopoietic stem and progenitor cells of both the fetus and adults. Moreover, further investigations of the associations between maternal vitamin D levels and cord blood immune cell profiles from 75 healthy pregnant women and their term offspring also confirm that maternal vitamin D levels in the second trimester significantly affect immune cell proportions in the offspring. These findings imply that the differentiation properties of hematopoiesis act as long-term memories of prenatal vitamin D deficiency exposure in later life.
- Publication
Scientific Reports, 2024, Vol 14, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-024-70911-8