We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Demineralized Dentin Matrix Incorporated with rhBMP-2 Composite Graft for Treating Medication-Related Osteonecrosis of the Jaw.
- Authors
Ku, Jeong-Kui; Choi, Jin-Won; Song, Seung-Min; Yun, Pil-Young; Um, In-Woong; Leem, Dae Ho
- Abstract
Medication-Related Osteonecrosis of the Jaw (MRONJ) is characterized by bone exposure in the oral and maxillofacial region for more than eight weeks in patients treated with anti-resorptive agents, immunosuppressants, or anti-angiogenic agents, without prior radiation therapy or metastatic disease to the jaws. Conservative treatments can control infection in mild cases, but surgical intervention is necessary for patients with severe symptoms. A 78-year-old female with a history of bisphosphonate treatment for osteoporosis presented with persistent pain, swelling, and malodor following implant placement in the upper right maxilla. SPECT/CT imaging revealed a high-risk hot spot in the right maxillary region. BIS-guided surgery using the Qray pen-C was performed, selectively removing red fluorescent bone tissue. The defect was grafted with HuBT incorporated with rhBMP-2. Postoperative follow-ups at 4, 7, and 14 months showed successful bone healing, transforming into a corticocancellous complex, and implant placement without MRONJ recurrence. Allogeneic demineralized dentin matrix (DDM) incorporated with rhBMP-2 demonstrates effective bone healing and implant placement following BIS-guided MRONJ surgery. This case supports the use of DDM/rhBMP-2 for tissue regeneration in MRONJ treatment, enabling successful prosthetic restoration without recurrence.
- Subjects
BONE regeneration; HEALING; COMPUTED tomography; IMAGING systems; JAW diseases; RADIOTHERAPY
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 16, p4830
- ISSN
2077-0383
- Publication type
Case Study
- DOI
10.3390/jcm13164830