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- Title
The Effects of Omega-3 and Melatonin Supplementation Associated with Moderate Physical Exercise on Biochemical Parameters, Hippocampus Morphometry, and Memory in Wistar Rats.
- Authors
Dutra Pereira, Danielle; Ketruy de Oliveira, Wanessa Noadya; Vieira Fialho, Gilberto; de Assis Lima, Wedja Stephany; Santos da Silva, Jeine Emanuele; de Souza Elias, Laíse; Álvaro Aguiar, Leandro; da Silva Almeida, Thaís Heloise; Fabricio de Souza, Raphael; Evêncio-Neto, Joaquim
- Abstract
The purpose of this study was to evaluate the effects of omega-3 and melatonin supplementation associated with moderate exercise. Sixty-day-old rats were divided into 8 Experimental Groups (n = 5 animals per group) according to the treatment: (1) A, omega-3; (2) B, melatonin; (3) C, physical exercise; (4) D, omega-3 and melatonin; (5) E, omega-3 and exercise; (6) F, melatonin and exercise; (7) G, omega-3, melatonin, and exercise; and (8) H, Control. The body mass at 30 days postnatal (M30) of the animals in B Group (42.47 ± 1.23) was lower compared to all Groups. At 60 days postnatal (M60), A (198.4 ± 4.15), B (213.3 ± 3.63), and C Groups (208.8 ± 6.11) presented higher body weight than the F Group (161.5 ± 6.37) and the H group (151.8 ± 4.80). The G group (172.4 ± 6.42) had a lower mean body weight than the B Group. At 30 days of age, VLDL (79.08 ± 12.89) and triglyceride (395.4 ± 64.43) in the F Group were higher than the B Group (30.44 ± 3.34 and 152.2 ± 16.9 respectively). After 60 days, the HDL levels of the F Group (77.13 ± 13.32) had increased higher than the D Group (25.98 ± 2.51). Regarding the glycemic response, the D Group (248.2 ± 24.48) was higher than all the Groups, while the H Group (155.6 ± 16.80) differed from the A, C, and F Groups. Regarding hippocampal morphometry at M30, only the D Group differed from the A and G Groups, presenting a higher neuronal density. At M60, the B Group presented a higher number of neurons than the A, C, E, F, and H Groups. The C group demonstrated neuronal reduction in relation to the A, D, E, F, and G Groups. When D was observed, it demonstrated a greater number of neurons than the A, E, F, and H Groups. Finally, the H Group had lower neuronal density when compared to the A, E, F, and G Groups. For the recognition test, there were no differences between the evaluated treatments at 30 and 60 days of age. Physical exercise related to omega-3 and melatonin supplementation after 30 and 60 days resulted in changes in body weight, biochemical parameters, and hippocampus morphometry, but did not interfere with the memory of Wistar Rats.
- Subjects
EXERCISE; MORPHOMETRICS; MELATONIN; HIPPOCAMPUS (Brain); BODY weight; RATS; MEMORY; EXPERIMENTAL groups
- Publication
Journal of Exercise Physiology Online, 2019, Vol 22, Issue 5, p200
- ISSN
1097-9751
- Publication type
Article