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- Title
Mechanical Induction of BMP-7 in Osteocyte Blocks Glucocorticoid-Induced Apoptosis Through PI3K/AKT/GSK3β Pathway.
- Authors
Wang, Zhaohong; Guo, Jun
- Abstract
Mechanical loading is known to promote osteocyte survival, whereas glucocorticoid treatment results in osteocyte apoptosis. Here, we report that BMP-7, which was secreted by osteocyte in response to mechanical loading, exerts anti-apoptotic effect against dexamethasone-induced apoptosis of osteocytes. We further show that the anti-apoptotic effect of BMP-7 is mainly mediated through receptor BMPR2 and is associated with the activation of PI3K/AKT/GSK3β pathway.
- Subjects
BONE morphogenetic proteins; OSTEOCYTES; GLUCOCORTICOIDS; APOPTOSIS; MECHANICAL loads; PROTEIN kinase B
- Publication
Cell Biochemistry & Biophysics, 2013, Vol 67, Issue 2, p567
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-013-9543-6