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- Title
Ameliorative effect of betulin from Betula platyphylla bark on scopolamine-induced amnesic mice.
- Authors
Cho, Namki; Kim, Hyeon Woo; Lee, Hee Kyoung; Jeon, Byung Ju; Sung, Sang Hyun
- Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease induced by cholinergic neuron damage or amyloid-beta aggregation in the basal forebrain region and resulting in cognitive disorder. We previously reported on the neuroprotective effects ofBetula platyphyllabark (BPB) in an amyloid-beta-induced amnesic mouse model. In this study, we obtained a cognitive-enhancing compound by assessing results using a scopolamine-induced amnesic mouse model. Our results show that oral treatment of mice with BPB and betulin significantly ameliorated scopolamine-induced memory deficits in both passive avoidance and Y-maze tests. In the Morris water maze test, administration of BPB and betulin significantly improved memory and cognitive function indicating the formation of working and reference memories in treated mice. Moreover, betulin significantly increased glutathione content in mouse hippocampus, and the increase was greater than that from betulinic acid treatment. We conclude that BPB and its active component betulin have potential as therapeutic, cognitive enhancer in AD. Betulin and BPB Significantly Ameliorated Scopolamine-Induced Memory Deficits in Mice in the Passive Avoidance, Y-maze, and Water Maze Tests.
- Subjects
BETULIN; SCOPOLAMINE; AMNESIA; ANIMAL models in research
- Publication
Bioscience, Biotechnology & Biochemistry, 2016, Vol 80, Issue 1, p166
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2015.1072460