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- Title
Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007).
- Authors
Coyle, V. J.; Rassnick, K. M.; Borst, L. B.; Rodriguez, C. O.; Northrup, N. C.; Fan, T. M.; Garrett, L. D.
- Abstract
The purpose of this retrospective study was to describe the biological behaviour of canine mandibular osteosarcoma ( OSA) and to examine factors for their impact on metastasis-free interval ( MFI) and survival time ( ST). Records from dogs treated with mandibulectomy for OSA (1999-2007) were reviewed. Archived tumour samples were evaluated for mitotic index ( MI) and tumour grade. Fifty dogs were included, 21 received chemotherapy. Twenty-nine dogs (58%) developed metastatic disease. The median MFI was 627 days, and median ST was 525 days. In univariate analysis MI > 40 was prognostic for decreased MFI and ST. Grade also influenced MFI and ST, with 5/21 (24%) dogs with grade II/ III tumours metastasis-free at one year versus 16/22 (72%) dogs with grade I tumours ( P = 0.002); and 5/21 (24%) dogs with grade II/ III tumours alive versus 17/22 (77%) dogs with grade I tumours ( P = 0.001). In multivariate analysis, histological grade and adjuvant chemotherapy were prognostic for MFI and ST.
- Subjects
OSTEOSARCOMA in dogs; CANCER in dogs; DOG diseases; OSTEOSARCOMA; DOG behavior; BONE cancer
- Publication
Veterinary & Comparative Oncology, 2015, Vol 13, Issue 2, p89
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/vco.12020