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- Title
Effect of Acupuncture for Radioactive-Iodine-Induced Anorexia in Thyroid Cancer Patients: A Randomized, Double-Blinded, Sham-Controlled Pilot Study.
- Authors
Jeon, Ju-Hyun; Yoon, Jeungwon; Cho, Chong-Kwan; Jung, In-Chul; Kim, Sungchul; Lee, Suk-Hoon; Yoo, Hwa-Seung
- Abstract
Objective. The aim of this study is to evaluate the efficacy and safety of acupuncture for radioactive iodine (RAI)–induced anorexia in thyroid cancer patients. Methods. Fourteen thyroid cancer patients with RAI-induced anorexia were randomized to a true acupuncture or sham acupuncture group. Both groups were given 6 true or sham acupuncture treatments in 2 weeks. Outcome measures included the change of the Functional Assessment of Anorexia and Cachexia Treatment (FAACT; Anorexia/Cachexia Subscale [ACS], Functional Assessment of Cancer Therapy–General [FACT-G]), Visual Analogue Scale (VAS), weight, body mass index (BMI), ACTH, and cortisol levels. Results. The mean FAACT ACS scores of the true and sham acupuncture groups increased from baseline to exit in intention-to-treat (ITT) and per protocol (PP) analyses; the true acupuncture group showed higher increase but with no statistical significance. Between groups, from baseline to the last treatment, statistically significant differences were found in ITT analysis of the Table of Index (TOI) score (P = .034) and in PP analysis of the TOI (P = .016), FACT-G (P = .045), FAACT (P = .037) scores. There was no significant difference in VAS, weight, BMI, ACTH, and cortisol level changes between groups. Conclusion. Although the current study is based on a small sample of participants, our findings support the safety and potential use of acupuncture for RAI-induced anorexia and quality of life in thyroid cancer patients.
- Subjects
TUMOR treatment; CACHEXIA; ACUPUNCTURE; APPETITE loss; CANCER patients; DEMOGRAPHY; INFORMED consent (Medical law); EVALUATION of medical care; PHYSICAL diagnosis; QUALITY of life; RADIOISOTOPES; SAFETY; DATA analysis; RANDOMIZED controlled trials; VISUAL analog scale; HUMAN research subjects; PATIENT selection; DIAGNOSIS
- Publication
Integrative Cancer Therapies, 2015, Vol 14, Issue 3, p221
- ISSN
1534-7354
- Publication type
Article
- DOI
10.1177/1534735415570634