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- Title
A Phototheranostic Strategy to Continuously Deliver Singlet Oxygen in the Dark and Hypoxic Tumor Microenvironment.
- Authors
Zou, Jianhua; Zhu, Jianwei; Yang, Zhen; Li, Ling; Fan, Wenpei; He, Liangcan; Tang, Wei; Deng, Liming; Mu, Jing; Ma, Yuanyuan; Cheng, Yaya; Huang, Wei; Dong, Xiaochen; Chen, Xiaoyuan
- Abstract
Continuous irradiation during photodynamic therapy (PDT) inevitably induces tumor hypoxia, thereby weakening the PDT effect. In PDT‐induced hypoxia, providing singlet oxygen from stored chemical energy may enhance the cell‐killing effect and boost the therapeutic effect. Herein, we present a phototheranostic (DPPTPE@PEG‐Py NPs) prepared by using a 2‐pyridone‐based diblock polymer (PEG‐Py) to encapsulate a semiconducting, heavy‐atom‐free pyrrolopyrrolidone‐tetraphenylethylene (DPPTPE) with high singlet‐oxygen‐generation ability both in dichloromethane and water. The PEG‐Py can trap the 1O2 generated from DPPTPE under laser irradiation and form a stable intermediate of endoperoxide, which can then release 1O2 in the dark, hypoxic tumor microenvironment. Furthermore, fluorescence‐imaging‐guided phototherapy demonstrates that this phototheranostic could completely inhibit tumor growth with the help of laser irradiation.
- Subjects
TUMOR microenvironment; TREATMENT effectiveness; PHOTODYNAMIC therapy; TUMOR growth; CHEMICAL energy; COBALT chloride; REACTIVE oxygen species
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 23, p8918
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201914384