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- Title
Response‐Retaliation Behavior in Synthetic Protocell Communities.
- Authors
Qiao, Yan; Li, Mei; Qiu, Dong; Mann, Stephen
- Abstract
Two different artificial predation strategies are spatially and temporally coupled to generate a simple tit‐for‐tat mechanism in a ternary protocell network capable of antagonistic enzyme‐mediated interactions. The consortium initially consists of protease‐sensitive glucose‐oxidase‐containing proteinosomes (1), non‐interacting pH‐sensitive polypeptide/mononucleotide coacervate droplets containing proteinase K (2), and proteinosome‐adhered pH‐resistant polymer/polysaccharide coacervate droplets (3). On receiving a glucose signal, secretion of protons from 1 triggers the disassembly of 2 and the released protease is transferred to 3 to initiate a delayed contact‐dependent killing of the proteinosomes and cessation of glucose oxidase activity. Our results provide a step towards complex mesoscale dynamics based on programmable response‐retaliation behavior in artificial protocell consortia.
- Subjects
COMMUNITIES; PROTEINASES; GLUCOSE oxidase; BEHAVIOR; DROPLETS; CONSORTIA; AMINE oxidase
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 49, p17922
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201909313