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- Title
Enantioselective Intramolecular Copper‐Catalyzed Borylacylation.
- Authors
Whyte, Andrew; Burton, Katherine I.; Zhang, Jingli; Lautens, Mark
- Abstract
An enantioselective copper‐catalyzed intramolecular borylacylation is reported. The reaction proceeds through an initial enantioselective borylcupration of the styrene, followed by a nucleophilic attack on the tethered carbamoyl chloride. The products, chiral borylated 3,3‐disubstituted oxindoles, were generated in excellent yields and enantioselectivities. The versatile carbon–boron bond provides a platform for a wide array of diversification.
- Subjects
ACYLATION; COPPER catalysts; ENANTIOSELECTIVE catalysis; CARBAMOYL compounds; OXINDOLES
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 42, p14123
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201808460