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- Title
Metal-Free Synthesis of Highly Substituted Pyridines by Formal [2+2+2] Cycloaddition under Mild Conditions.
- Authors
Xie, Lan ‐ Gui; Shaaban, Saad; Chen, Xiangyu; Maulide, Nuno
- Abstract
The synthesis of pyridines through direct intermolecular cycloaddition of alkynes and nitriles is a contemporary challenge in organic synthesis. A Brønsted acid mediated formal [2+2+2] cycloaddition of heteroalkynes and nitriles was developed that proceeds under mild conditions. This constitutes a modular approach to highly substituted pyridine cores.
- Subjects
PYRIDINE synthesis; BRONSTED acids; SUBSTITUTION reactions; RING formation (Chemistry); ALKYNE derivatives; NITRILES
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 41, p13056
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201606604