We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Bright, "Clickable" Porphyrins for the Visualization of Oxygenation under Ambient Light.
- Authors
Roussakis, Emmanuel; Li, Zongxi; Nowell, Nicholas H.; Nichols, Alexander J.; Evans, Conor L.
- Abstract
A new group of "clickable" and brightly emissive metalloporphyrins has been developed for the visualization of oxygenation under ambient light with the naked eye. These alkynyl-terminated compounds permit the rapid and facile synthesis of oxygen-sensing dendrimers through azide-alkyne click chemistry. With absorption maxima overlapping with the wavelengths of common commercial laser sources, they are readily applicable to biomedical imaging of tissue oxygenation. An efficient synthetic methodology, featuring the stable trimethylacetyl (pivaloyl) protecting group, is described for their preparation. A paint-on liquid bandage containing a new, click-synthesized porphyrin dendrimer has been used to map oxygenation across an ex vivo porcine skin burn model.
- Subjects
PORPHYRINS; LUMINESCENCE; BIOTECHNOLOGY; DENDRIMERS; OXYGENATION (Chemistry); WAVELENGTHS
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 49, p14941
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201506847