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Berichtigung: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
- Published in:
- Angewandte Chemie, 2016, v. 128, n. 36, p. 10704, doi. 10.1002/ange.201607032
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- Publication type:
- Article
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
- Published in:
- Angewandte Chemie, 2016, v. 128, n. 22, p. 6511, doi. 10.1002/ange.201512062
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- Publication type:
- Article
Corrigendum: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
- Published in:
- Angewandte Chemie International Edition, 2016, v. 55, n. 36, p. 10548, doi. 10.1002/anie.201607032
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- Publication type:
- Article
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
- Published in:
- Angewandte Chemie International Edition, 2016, v. 55, n. 22, p. 6401, doi. 10.1002/anie.201512062
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- Publication type:
- Article
A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle.
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- Angewandte Chemie International Edition, 2015, v. 54, n. 46, p. 13504, doi. 10.1002/anie.201507264
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- Publication type:
- Article
A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose Trial of AWZ1066S, an Anti‐Wolbachia Candidate Macrofilaricide.
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- Clinical Pharmacology in Drug Development, 2024, v. 13, n. 9, p. 1071, doi. 10.1002/cpdd.1441
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- Publication type:
- Article
Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23313-7
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- Publication type:
- Article
Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains.
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- Journal of Molecular Modeling, 2018, v. 24, n. 9, p. 1, doi. 10.1007/s00894-018-3755-z
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- Publication type:
- Article
Ein Chinolincarboxamid als Breitbandwirkstoff gegen Malaria: Angriff in drei parasitären Stadien.
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- Angewandte Chemie, 2015, v. 127, n. 46, p. 13706, doi. 10.1002/ange.201507264
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- Publication type:
- Article
Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins.
- Published in:
- Angewandte Chemie, 2010, v. 122, n. 33, p. 5829, doi. 10.1002/ange.201001026
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- Publication type:
- Article
Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD.
- Published in:
- Scientific Reports, 2016, p. 36777, doi. 10.1038/srep36777
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- Publication type:
- Article
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
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- Molecular Microbiology, 2006, v. 62, n. 1, p. 238, doi. 10.1111/j.1365-2958.2006.05368.x
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- Publication type:
- Article
Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement.
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- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-62903-5
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- Publication type:
- Article
Dose prediction for repurposing nitazoxanide in SARS‐CoV‐2 treatment or chemoprophylaxis.
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- British Journal of Clinical Pharmacology, 2021, v. 87, n. 4, p. 2078, doi. 10.1111/bcp.14619
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- Publication type:
- Article
Antimalarial activity of primaquine operates via a two-step biochemical relay.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-11239-0
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- Publication type:
- Article
Control and regulation of S‐Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone‐based compounds.
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- FEBS Journal, 2019, v. 286, n. 11, p. 2135, doi. 10.1111/febs.14790
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- Publication type:
- Article
Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy.
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- Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-0826-3
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- Publication type:
- Article
Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies.
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- Medicinal Research Reviews, 2021, v. 41, n. 6, p. 3062, doi. 10.1002/med.21849
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- Article
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
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- Nature Communications, 2017, v. 8, n. 5, p. 15159, doi. 10.1038/ncomms15159
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- Publication type:
- Article
Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics.
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- Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 4, p. 775, doi. 10.1002/cpt.1909
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- Article
Design and Synthesis of Endoperoxide Antimalarial Prodrug ModelsThis work was supported by grants from the BBSRC (UK) for P.A.S., P.O'N., and S.A.W. (26/B13581) and from the EPSRC (UK) for M.D.P.
- Published in:
- Angewandte Chemie, 2004, v. 116, n. 32, p. 4289, doi. 10.1002/ange.200453859
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- Publication type:
- Article
On the ordeal of quinolone preparation via cyclisation of aryl-enamines; synthesis and structure of ethyl 6-methyl-7-iodo-4-(3-iodo-4-methylphenoxy)-quinoline-3- carboxylate.
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- Pure & Applied Chemistry, 2017, v. 89, n. 6, p. 765, doi. 10.1515/pac-2016-1119
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- Publication type:
- Article
Medicinal chemistry: A worthy adversary for malaria.
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- Nature, 2004, v. 430, n. 7002, p. 838, doi. 10.1038/430838a
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- Article
Targeting the Ubiquinol-Reduction (Q i) Site of the Mitochondrial Cytochrome bc 1 Complex for the Development of Next Generation Quinolone Antimalarials.
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- Biology (2079-7737), 2022, v. 11, n. 8, p. N.PAG, doi. 10.3390/biology11081109
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- Article
Safety assessment of peroxide antimalarials: clinical and chemical perspectives.
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- British Journal of Clinical Pharmacology, 1998, v. 46, n. 6, p. 521, doi. 10.1046/j.1365-2125.1998.00838.x
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- Article
The biological evaluation of fusidic acid and its hydrogenation derivative as antimicrobial and anti-inflammatory agents.
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- Infection & Drug Resistance, 2018, v. 11, p. 1945, doi. 10.2147/IDR.S176390
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- Publication type:
- Article
Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials.
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- Molecular Medicine, 2012, v. 18, n. 7, p. 1045, doi. 10.2119/molmed.2012.00154
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- Publication type:
- Article
Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2023.1331224
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- Publication type:
- Article
Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2023.1328950
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- Publication type:
- Article
The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04114-x
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- Publication type:
- Article
Design and Synthesis of Endoperoxide Antimalarial Prodrug ModelsThis work was supported by grants from the BBSRC (UK) for P.A.S., P.O'N., and S.A.W. (26/B13581) and from the EPSRC (UK) for M.D.P.
- Published in:
- Angewandte Chemie International Edition, 2004, v. 43, n. 32, p. 4193, doi. 10.1002/anie.200453859
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- Publication type:
- Article
Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation.
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- Allergy, 2020, v. 75, n. 3, p. 636, doi. 10.1111/all.14057
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- Publication type:
- Article
Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis—A Short Bridge between Two Distant Illnesses.
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- Molecules, 2020, v. 25, n. 7, p. 1574, doi. 10.3390/molecules25071574
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- Article
The Molecular Mechanism of Action of Artemisinin-The Debate Continues.
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- Molecules, 2010, v. 15, n. 3, p. 1705, doi. 10.3390/molecules15031705
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- Article
An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites.
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- ChemMedChem, 2013, v. 8, n. 9, p. 1528, doi. 10.1002/cmdc.201300202
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- Article
Inside Cover: Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (ChemMedChem 5/2013).
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- ChemMedChem, 2013, v. 8, n. 5, p. 674, doi. 10.1002/cmdc.201390016
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- Publication type:
- Article
Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation.
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- ChemMedChem, 2013, v. 8, n. 5, p. 709, doi. 10.1002/cmdc.201200536
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- Publication type:
- Article
Synthesis and Antimalarial Activities of a Diverse Set of Triazole-Containing Furamidine Analogues.
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- ChemMedChem, 2011, v. 6, n. 11, p. 2094, doi. 10.1002/cmdc.201100265
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- Publication type:
- Article
Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action.
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- ChemMedChem, 2011, v. 6, n. 8, p. 1357, doi. 10.1002/cmdc.201100196
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- Publication type:
- Article
Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH: quinone oxidoreductase.
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- 2010
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- Publication type:
- Abstract
A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum.
- Published in:
- 2010
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- Publication type:
- Abstract
Enantiomeric 1,2,4-Trioxanes Display Equivalent in vitro Antimalarial Activity Versus Plasmodium falciparum Malaria Parasites: Implications for the Molecular Mechanism of Action of the Artemisinins.
- Published in:
- ChemBioChem, 2005, v. 6, n. 11, p. 2048, doi. 10.1002/cbic.200500048
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- Publication type:
- Article
Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential.
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- Journal of Antimicrobial Chemotherapy (JAC), 2014, v. 69, n. 4, p. 1005, doi. 10.1093/jac/dkt486
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- Publication type:
- Article
Antimalarial pharmacology and therapeutics of atovaquone.
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- Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 5, p. 977, doi. 10.1093/jac/dks504
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- Publication type:
- Article
Antitubercular pharmacodynamics of phenothiazines.
- Published in:
- Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 4, p. 869, doi. 10.1093/jac/dks483
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- Publication type:
- Article
Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins.
- Published in:
- Angewandte Chemie International Edition, 2010, v. 49, n. 33, p. 5693, doi. 10.1002/anie.201001026
- By:
- Publication type:
- Article
Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs.
- Published in:
- Angewandte Chemie International Edition, 2007, v. 46, n. 33, p. 6278, doi. 10.1002/anie.200604697
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- Publication type:
- Article