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- Title
Total Syntheses of (−)-Huperzine Q and (+)-Lycopladines B and C.
- Authors
Hong, Benke; Li, Houhua; Wu, Jinbao; Zhang, Jing; Lei, Xiaoguang
- Abstract
Utilizing a late-stage enamine bromofunctionalization strategy, the twelve-step total synthesis of (−)-huperzine Q was accomplished. Furthermore, the first total syntheses of (+)-lycopladines B and C are described. An unprecedented X-ray crystal structure of an unusual epoxyamine intermediate is also reported, and the synthetic application of this intermediate in natural product synthesis is demonstrated.
- Subjects
ACETYLCHOLINESTERASE inhibitors; ENAMINES; CLUB mosses; X-ray diffraction; SPECTROSCOPIC imaging
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 3, p1025
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201409503