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- Title
Stable Small Quantum Dots for Synaptic Receptor Tracking on Live Neurons.
- Authors
En Cai; Pinghua Ge; Sang Hak Lee; Jeyifous, Okunola; Yong Wang; Yanxin Liu; Wilson, Katie M.; Sung Jun Lim; Baird, Michelle A.; Stone, John E.; Kwan Young Lee; Davidson, Michael W.; Hee Jung Chung; Schulten, Klaus; Smith, Andrew M.; Green, William N.; Selvin, Paul R.
- Abstract
We developed a coating method to produce functionalized small quantum dots (sQDs), about 9 nm in diameter, that were stable for over a month. We made sQDs in four emission wavelengths, from 527 to 655 nm and with different functional groups. AMPA receptors on live neurons were labeled with sQDs and postsynaptic density proteins were visualized with super-resolution microscopy. Their diffusion behavior indicates that sQDs access the synaptic clefts significantly more often than commercial QDs.
- Subjects
QUANTUM dot synthesis; AMPA receptors; SEMICONDUCTOR nanocrystals; PARTICLE tracks (Nuclear physics); HIGH resolution imaging; POSTSYNAPTIC density protein; NEURON analysis; FLUORESCENCE spectroscopy
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 46, p12692
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201405735