We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Spatial regulation and organization of DNA replication within the nucleus.
- Authors
Natsume, Toyoaki; Tanaka, Tomoyuki
- Abstract
Duplication of chromosomal DNA is a temporally and spatially regulated process. The timing of DNA replication initiation at various origins is highly coordinated; some origins fire early and others late during S phase. Moreover, inside the nuclei, the bulk of DNA replication is physically organized in replication factories, consisting of DNA polymerases and other replication proteins. In this review article, we discuss how DNA replication is organized and regulated spatially within the nucleus and how this spatial organization is linked to temporal regulation. We focus on DNA replication in budding yeast and fission yeast and, where applicable, compare yeast DNA replication with that in bacteria and metazoans.
- Subjects
DNA replication; CHROMOSOMES; DNA polymerases; METAZOA; BACTERIA
- Publication
Chromosome Research, 2010, Vol 18, Issue 1, p7
- ISSN
0967-3849
- Publication type
Article
- DOI
10.1007/s10577-009-9088-0