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- Title
Complete and regioselective deacetylation of peracetylated uridines using a lipase.
- Authors
Iglesias, Luis E.; Zinni, María A.; Gallo, Mariana; Iribarren, Adolfo M.
- Abstract
Lipase-catalysed alcoholysis and hydrolysis of 2′,3′,5′-tri-O-acetyluridine (1a) and 2′,3′,5′-tri-O-acetyl-2′-C-methyluridine (1b) were studied. Conditions for full and regioselective deacetylation of 1a and 1b are shown in the present work. New compound 2′,3′-di-O-acetyl-2′-C-methyluridine (3b) was prepared by regioselective lipase-catalysed deacetylation.
- Subjects
LIPASES; HYDROLASES; ALCOHOLYSIS; HYDROLYSIS; CATALYSTS; BIOCHEMISTRY
- Publication
Biotechnology Letters, 2000, Vol 22, Issue 5, p361
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1023/A:1005620617554