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- Title
Synthesis, characterization and anti-diabetic therapeutic potential of a new benzyl acid-derivatized kojic acid vanadyl complex.
- Authors
Wei, Yong-Biao; Yang, Xiao-Da
- Abstract
Vanadium complexes are potent hypoglycemic agents and of great potential for therapeutical treatment of diabetes. In the present work, a novel vanadium compound, bis ((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl benzoatato) oxovanadium (IV) (BBOV) has been synthesized. Treatment of STZ-induced diabetic rats with BBOV restored the blood glucose to normal level and ameliorated glucose tolerance. The hypoglycemic effect of BBOV is similar to that of bis (maltolato) oxovanadium but is less toxic in median lethal dose. Overall, the present work will provide useful information for further development of new anti-diabetic vanadium compounds.
- Subjects
TREATMENT of diabetes; BLOOD sugar; ANTIOXIDANTS; VANADIUM compounds; LABORATORY rats
- Publication
BioMetals, 2012, Vol 25, Issue 6, p1261
- ISSN
0966-0844
- Publication type
Article
- DOI
10.1007/s10534-012-9587-x