We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Lisdexamfetamine dimesylate in binge eating disorder: a placebo controlled trial.
- Authors
Guerdjikova, Anna I.; Mori, Nicole; Blom, Thomas J.; Keck, Paul E.; Williams, Stephanie L.; Welge, Jeffrey A.; McElroy, Susan L.
- Abstract
Objective To evaluate lisdexamfetamine dimesylate (LDX) in the treatment of binge eating disorder (BED). Method Fifty participants with BED received LDX (20-70 mg/day) ( n = 25) or placebo ( n = 25) for up to 12 weeks in a single-center, randomized, double-blind, and flexible-dose trial. The primary outcome measure was binge eating (BE) days/week. Results In the primary longitudinal analysis, compared with placebo, LDX was not associated with a significantly greater rate of reduction in BE days/week, as well as BE episodes/week, and scores on the Clinical Global Impression-Severity or Yale-Brown Obsessive-Compulsive Scale modified for binge eating scales. It was, however, associated with significantly decreased weight, body mass index, and fasting triglyceride level. In the secondary last observation carried forward analyses, LDX was associated with statistically significant reductions in BE days/week, BE episodes/week, weight, and BMI, as well as a statistically significant greater level of categorical response and global improvement. The mean (standard deviation) LDX daily dose at endpoint evaluation was 59.6 (14.9) mg. One participant discontinued LDX for a serious adverse cardiovascular event, which resolved fully. Conclusion Lisdexamfetamine dimesylate may have clinical utility for BED but further studies of its efficacy, tolerability, and safety in this population are needed. Copyright © 2016 John Wiley & Sons, Ltd.
- Subjects
BULIMIA treatment; METHANESULFONATES; PLACEBOS; CLINICAL trials; TREATMENT effectiveness; BODY mass index; THERAPEUTICS
- Publication
Human Psychopharmacology: Clinical & Experimental, 2016, Vol 31, Issue 5, p382
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.2547