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- Title
Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore-Tex<sup>®</sup>.
- Authors
Scuglia, Marianna; Frazão, Laura P.; Miranda, Alice; Martins, Albino; Barbosa-Sequeira, Joana; Coimbra, Diana; Longatto-Filho, Adhemar; Reis, Rui L.; Nogueira-Silva, Cristina; Neves, Nuno M.; Correia-Pinto, Jorge
- Abstract
Background: Patch repair of congenital diaphragmatic hernia (CDH) using Gore-Tex® is associated with infection, adhesions, hernia recurrence, long-term musculoskeletal sequels and poor tissue regeneration. To overcome these limitations, the performance of two novel biodegradable membranes was tested to repair CDH in a growing pig model. Methods: Twelve male pigs were randomly assigned to 3 different groups of 4 animals each, determined by the type of patch used during thoracoscopic diaphragmatic hernia repair (Gore-Tex®, polycaprolactone electrospun membrane-PCLem, and decellularized human chorion membrane-dHCM). After 7 weeks, all animals were euthanized, followed by necropsy for diaphragmatic evaluation and histological analysis. Results: Thoracoscopic defect creation and diaphragmatic repair were performed without any technical difficulty in all groups. However, hernia recurrence rate was 0% in Gore-Tex®, 50% in PCLem and 100% in dHCM groups. At euthanasia, Gore-Tex® patches appeared virtually unchanged and covered with a fibrotic capsule, while PCLem and dHCM patches were replaced by either floppy connective tissue or vascularized and floppy regenerated membranous tissue, respectively. Conclusion: Gore-Tex® was associated with a higher survival rate and lower recurrence. Nevertheless, the proposed biodegradable membranes were associated with better tissue integration when compared with Gore-Tex®.
- Subjects
DIAPHRAGMATIC hernia; HERNIA surgery; CONNECTIVE tissues; CHORION; AUTOPSY
- Publication
Pediatric Surgery International, 2023, Vol 40, Issue 1, p1
- ISSN
0179-0358
- Publication type
Article
- DOI
10.1007/s00383-023-05584-x