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- Title
Spinal cord transection inhibits HR reduction in anesthetized rats immersed in an artificial CO<sub>2</sub>-hot spring bath.
- Authors
Noriyuki Yamamoto; Masaaki Hashimoto
- Abstract
Abstract??Like humans, the heart rate (HR) of anesthetized rats immersed in CO2-water is lower than that when immersed in tap water at the same temperature. To investigate the afferent signal pathway in the mechanism of HR reduction, Wistar rats were anesthetized with urethane and then the spinal cord was transected between T4and T5. The animals were immersed up to the axilla in a bathtub of tap-water (CO2contents: 10?20?mg?l?1) or of CO2-water (965?1,400?mg?l?1) at 35?C while recording HR, arterial blood pressure, and arterial blood gas parameters (PaCO2,PaO2, pH). Arterial blood gas parameters did not change during immersion, irrespective of CO2concentration of the bath water, whereas the HR was reduced in the CO2-water bath. The inhalation of CO2-mixed gas (5 % CO2, 20 % O2, 75 % N2) resulted in increased levels of blood gases and an increased HR during immersion in all types of water tested. The HR reduction observed in sham transected control animals immersed in CO2-water disappeared after subsequent spinal cord transection. These results show that the dominant afferent signal pathway to the brain, which is involved in inducing the reduced HR during immersion in CO2-water, is located in the neuronal route and not in the bloodstream.
- Subjects
PHYSIOLOGICAL effects of heat; PHYSIOLOGICAL effects of carbon dioxide; SPINAL cord; HEART beat
- Publication
International Journal of Biometeorology, 2007, Vol 51, Issue 3, p201
- ISSN
0020-7128
- Publication type
Article