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- Title
A poly(propylene glycol-co-fumaric acid) based bone graft extender for lumbar spinal fusion: in vivo assessment in a rabbit model.
- Authors
Hile, David D.; Kandziora, Frank; Lewandrowski, Kai-Uwe; Doherty, Stephen A.; Kowaleski, Michael P.; Trantolo, Debra J.
- Abstract
<bold>Study Design: </bold>An animal model of posterolateral intertransverse process lumbar spinal fusion compared fusion rates amongst autologous bone (group 1), a porous, bioabsorbable, scaffold based on the biopolymer, poly(propylene glycol-co-fumaric acid) (PPF) (group 2), and a combination of autograft and the bioabsorbable scaffold (group 3).<bold>Objectives: </bold>To evaluate the feasibility of augmenting spinal fusion with an osteoconductive and bioabsorbable scaffold as an alternative or as an adjunct, i.e., an extender, to autograft.<bold>Summary Of Background Data: </bold>There is little preclinical data on applications of bioabsorable bone graft extenders in spinal fusion.<bold>Methods: </bold>New Zealand White rabbits underwent single-level lumbar posterolateral intertransverse process fusion. Animals were treated with one of three materials: autologous bone (group 1), a bioabsorable material based on PPF (group 2), and the PPF biopolymer scaffold with autologous bone graft (group 3). Animals were evaluated at 6 weeks, and fusion was evaluated by manual palpation, and radiographic, histologic, and histomorphometric analyses.<bold>Results: </bold>Radiographic and manual palpation showed evidence of fusion in all three groups. Histomorphometric measurement of bone ingrowth showed the highest quantity of new bone in group 3 (91%), followed by group 1 (72%) and group 2 (53%).<bold>Conclusions: </bold>Results of this study suggested that osteoconductive bioabsorbable scaffolds prepared from PPF might be used as an autograft extender when applied as an adjunct to spinal fusion.
- Subjects
SPINAL fusion; SPINAL surgery; BONE grafting; TRANSPLANTATION of organs, tissues, etc.; RABBITS; PROPENE; LUMBAR vertebrae surgery; POLYMERS; PROPYLENE glycols; BONE substitutes; ANIMAL experimentation; COMPARATIVE studies; LUMBAR vertebrae; MATERIALS testing; RESEARCH methodology; MEDICAL cooperation; PARTICLES; RESEARCH; SCANNING electron microscopy; EVALUATION research; ANATOMY; THERAPEUTICS
- Publication
European Spine Journal, 2006, Vol 15, Issue 6, p936
- ISSN
0940-6719
- Publication type
journal article
- DOI
10.1007/s00586-005-1001-8