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- Title
Combination of intratumoural micellar paclitaxel with radiofrequency ablation: efficacy and toxicity in rodents.
- Authors
Wu, Hao; Fan, Zhi-Pu; Jiang, An-Na; Di, Xing-Sheng; He, Bing; Wang, Song; Goldberg, S. Nahum; Ahmed, Muneeb; Zhang, Qiang; Yang, Wei
- Abstract
<bold>Objectives: </bold>To determine whether radiofrequency ablation (RFA) is more effective when combined with intratumoural injection (IT) than with intravenous injection (IV) of micelles.<bold>Materials and Methods: </bold>Balb/c mice bearing 4T1 breast cancer were used. The tumour drug accumulation and biodistribution in major organs were evaluated at different time points after IT, IV, IT+RFA and IV+RFA. Periablational drug penetration was evaluated by quantitative analysis and pathologic staining after different treatments. For long-term outcomes, mice bearing tumours were randomised into six groups (n = 7/group): the control, IV, IT, RFA alone, IV+RFA and IT+RFA groups. The end-point survival was estimated for the different treatment groups.<bold>Results: </bold>In vivo, intratumoural drug accumulation was always much higher for IT than for IV within 48 h (p < 0.001). The IT+RFA group (3084.7 ± 985.5 μm) exhibited greater and deeper drug penetration than the IV+RFA group (686.3 ± 83.7 μm, p < 0.001). Quantitatively, the intratumoural drug accumulation in the IT+RFA group increased approximately 4.0-fold compared with that in the IV+RFA group (p < 0.001). In addition, compared with the IT treatment, the IT+RFA treatment further reduced the drug deposition in the main organs. Survival was longer in the IT+RFA group than in the IV+RFA (p = 0.033) and RF alone (p = 0.003) groups.<bold>Conclusion: </bold>The use of IT+RFA achieved much deeper and greater intratumoural drug penetration and accumulation, resulting in better efficacy, and decreased the systemic toxicity of nanoparticle-delivered chemotherapy.<bold>Key Points: </bold>• Association of IT+RFA achieved much deeper and greater intratumoural drug penetration than of IV+RFA, leading to better therapeutic efficacy. • Compared with IV or IT chemotherapy alone, the combination with RFA decreased toxicity, especially in the IT+RFA group.
- Subjects
CATHETER ablation; TREATMENT effectiveness; PACLITAXEL; RODENTS; INTRAVENOUS injections
- Publication
European Radiology, 2019, Vol 29, Issue 11, p6202
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-019-06207-7