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- Title
Increased insular connectivity with emotional regions in primary insomnia patients: a resting-state fMRI study.
- Authors
Wang, Tianyue; Yan, Jianhao; Li, Shumei; Zhan, Wenfeng; Ma, Xiaofen; Xia, Likun; Li, Meng; Lin, Chulan; Tian, Junzhang; Li, Cheng; Jiang, Guihua
- Abstract
<bold>Objective: </bold>To explore the abnormal connectivity patterns between the insular and the voxels of the brain in primary insomnia (PI) with insular-based functional connectivity (FC).<bold>Methods: </bold>With the resting-state fMRI data acquired from 57 PI patients and 46 healthy controls, a two-sample t test was performed on individual FC correlation maps from two groups. The person correlation analysis was used to evaluate the relationship between the abnormal FC and clinical features.<bold>Results: </bold>PI patients show enhanced connectivity between the left insula with the right anterior cingulate cortex (p < 0.05 and p < 0.001, AlphaSim-corrected), right frontal sup orb, bilateral thalamus and left precuneus,as well as decreased connectivity with the left middle temporal gyrus and right fusiform (p < 0.05, AlphaSim-corrected). Correlation analysis indicated the enhanced connectivities in the PI patients have significant negative correlations with Self-Rating Depression Scale(SDS)and Self-Rating Anxiety Scale(SAS)scores. In addition, the decreased functional connectivities showed positive correlations with SDS and SAS scores.<bold>Conclusion: </bold>Our study showed the increased connectivity regions with insula were mainly in the emotional circle and decreased connectivity was in cognitive-related regions. These provide additional evidence from functional integration view to understand the possible underlying neural- mechanisms of PI.<bold>Key Points: </bold>• The aberrant insular-based connectivity pattern of PI patients was detected. • Regions showing increased connectivity with left insular were mainly in emotional circle. • Significant correlations between changed FC and SDS and SAS score were found.
- Subjects
INSOMNIACS; FUNCTIONAL magnetic resonance imaging; INSULAR cortex; CINGULATE cortex; THALAMUS; BRAIN; BRAIN mapping; INSOMNIA; MAGNETIC resonance imaging; CASE-control method; NEURAL pathways
- Publication
European Radiology, 2017, Vol 27, Issue 9, p3703
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4680-0