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- Title
Optimising MR perfusion imaging: comparison of different software-based approaches in acute ischaemic stroke.
- Authors
Schaafs, Lars-Arne; Porter, David; Audebert, Heinrich; Fiebach, Jochen; Villringer, Kersten; Audebert, Heinrich J; Fiebach, Jochen B
- Abstract
<bold>Objectives: </bold>Perfusion imaging (PI) is susceptible to confounding factors such as motion artefacts as well as delay and dispersion (D/D). We evaluate the influence of different post-processing algorithms on hypoperfusion assessment in PI analysis software packages to improve the clinical accuracy of stroke PI.<bold>Methods: </bold>Fifty patients with acute ischaemic stroke underwent MRI imaging in the first 24 h after onset. Diverging approaches to motion and D/D correction were applied. The calculated MTT and CBF perfusion maps were assessed by volumetry of lesions and tested for agreement with a standard approach and with the final lesion volume (FLV) on day 6 in patients with persisting vessel occlusion.<bold>Results: </bold>MTT map lesion volumes were significantly smaller throughout the software packages with correction of motion and D/D when compared to the commonly used approach with no correction (p = 0.001-0.022). Volumes on CBF maps did not differ significantly (p = 0.207-0.925). All packages with advanced post-processing algorithms showed a high level of agreement with FLV (ICC = 0.704-0.879).<bold>Conclusions: </bold>Correction of D/D had a significant influence on estimated lesion volumes and leads to significantly smaller lesion volumes on MTT maps. This may improve patient selection.<bold>Key Points: </bold>• Assessment on hypoperfusion using advanced post-processing with correction for motion and D/D. • CBF appears to be more robust regarding differences in post-processing. • Tissue at risk is estimated more accurately by correcting software algorithms. • Advanced post-processing algorithms show a higher agreement with the final lesion volume.
- Subjects
MAGNETIC resonance angiography; STROKE; ISCHEMIA; VOLUME (Cubic content); MAGNETIC resonance; MAGNETIC resonance imaging; ALGORITHMS; CEREBRAL circulation; COMPARATIVE studies; COMPUTER software; RESEARCH methodology; MEDICAL cooperation; PERFUSION; RADIONUCLIDE imaging; RESEARCH; EVALUATION research
- Publication
European Radiology, 2016, Vol 26, Issue 11, p4204
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4244-3