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- Title
Signal intensity change on unenhanced T1-weighted images in dentate nucleus following gadobenate dimeglumine in patients with and without previous multiple administrations of gadodiamide.
- Authors
Ramalho, Joana; Semelka, Richard; AlObaidy, Mamdoh; Ramalho, Miguel; Nunes, Renato; Castillo, Mauricio; Semelka, Richard C; Nunes, Renato H
- Abstract
<bold>Objectives: </bold>To evaluate the impact of previous administration of gadodiamide and neural tissue gadolinium deposition in patients who received gadobenate dimeglumine.<bold>Methods: </bold>Our population included 62 patients who underwent at least three administrations of gadobenate dimeglumine, plus an additional contrast-enhanced last MRI for reference, divided into two groups: group 1, patients who in addition to gadobenate dimeglumine administrations had prior exposure to multiple doses of gadodiamide; group 2, patients without previous exposure to other gadolinium-based contrast agent (GBCAs). Quantitative analysis was performed on the first and last gadobenate dimeglumine MRIs in both groups. Dentate nucleus-to-middle cerebellar peduncle signal intensity ratios (DN/MCP) and relative change (RC) in signal over time were calculated and compared between groups using generalized additive model.<bold>Results: </bold>Group 1 showed significant increase in baseline and follow-up DN/MCP compared to group 2 (p < 0.0001). The RC DN/MCP showed a non-statistically significant trend towards an increase in patients who underwent previous gadodiamide (p = 0.0735).<bold>Conclusion: </bold>There is increased T1 signal change over time in patients who underwent gadobenate dimeglumine and had received prior gadodiamide compared to those without known exposure to previous gadodiamide. A potentiating effect from prior gadodiamide on subsequent administered gadobenate dimeglumine may occur.<bold>Key Points: </bold>• Neural gadolinium deposition is associated with multiple administrations of less stable GBCAs. • Less stable GBCA effect on subsequent more stable GBCA administrations is undetermined. • Significant increase of DN/MCP was seen in patients with previous gadodiamide exposure. • RC DN/MCP showed a non-significant increase in patients who received previous gadodiamide. • Potentiating effects from prior gadodiamide on subsequent administered gadobenate dimeglumine may occur.
- Subjects
NERVE tissue; GADOLINIUM; GADOLINIUM compounds; MAGNETIC resonance imaging; NERVOUS system; CEREBELLUM; CHEMICAL elements; COMPARATIVE studies; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; ORGANOMETALLIC compounds; RESEARCH; SORBITOL; EVALUATION research; CONTRAST media; DRUG administration; DRUG dosage
- Publication
European Radiology, 2016, Vol 26, Issue 11, p4080
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4269-7