We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site.
- Authors
Zhang, Shui-Xing; Jia, Qian-Jun; Zhang, Zhong-Ping; Liang, Chang-Hong; Chen, Wen-Bo; Qiu, Qian-Hui; Li, He
- Abstract
<bold>Objectives: </bold>We compared pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) based on intravoxel incoherent motion (IVIM) theory in patients with nasopharyngeal carcinoma (NPC).<bold>Methods: </bold>Sixty-five consecutive patients (48 men) with suspected NPC were examined using a 3.0-T MR system. Diffusion-weighted imaging (DWI) was performed with 13 b values (range, 0-800 s/mm(2)). We regarded the result of endoscopy and biopsy as the gold standard for detection. D, D* and f were compared between patients with primary NPC and enlarged adenoids.<bold>Results: </bold>IVIM DWI was successful in 37 of 40 NPC and 23 of 25 enlarged adenoids cases. D (P = 0.001) and f (P < 0.0001) were significantly lower in patients with NPC than in patients with enlarged adenoids, whereas D* was significantly higher (P < 0.0001). However, the ADC was not significantly different between the two groups (P > 0.05). The area under the ROC curve (AUC) for D was 0.849 and was significantly larger than that for ADC (P < 0.05).<bold>Conclusions: </bold>IVIM DWI is a feasible technique for investigating primary NPC. D was significantly decreased in primary NPC, and increased D* reflected increased blood vessel generation and parenchymal perfusion in primary NPC.<bold>Key Points: </bold>• Intravoxel incoherent motion (IVIM) analysis permits separate quantification of diffusion and perfusion. • IVIM DWI is a feasible technique for investigating primary NPC. • IVIM suggests that primary NPC tissue voxels exhibit both perfusion and diffusion.
- Publication
European Radiology, 2014, Vol 24, Issue 8, p1998
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-014-3203-0