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- Title
64-row MDCT perfusion of head and neck squamous cell carcinoma: technical feasibility and quantitative analysis of perfusion parameters.
- Authors
Faggioni L; Neri E; Cerri F; Picano E; Seccia V; Muscatello L; Franceschini SS; Bartolozzi C; Faggioni, Lorenzo; Neri, Emanuele; Cerri, Francesca; Picano, Eugenia; Seccia, Veronica; Muscatello, Luca; Franceschini, Stefano Sellari; Bartolozzi, Carlo
- Abstract
<bold>Objectives: </bold>To evaluate the technical feasibility of 64-row computed tomography (CT) quantitative perfusion imaging of head and neck squamous cell carcinoma (SCC).<bold>Methods: </bold>Twenty-nine patients with a total of 29 pathologically proven SCC underwent a cine-mode CT perfusion acquisition covering the lesion site. The acquisition started 10 s after intravenous injection of iodinated contrast material and lasted 50 s. On a dedicated workstation, regions of interest (ROI) were traced within the SCC, on a healthy portion of tissue (H), and on the ipsilateral sternocleidomastoid muscle (M). Blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability-surface product (PS) were calculated.<bold>Results: </bold>In SCC, BF, BV and PS were higher compared with H (p<0.0001, p=0.002 and p=0.004, respectively) and M (p<0.0001). Conversely, MTT was lower in SCC than in H (p=0.0009) and M (p=0.0003). All datasets were free from substantial motion artefacts and ROI misregistration phenomena. No substantial discomfort or adverse events were experienced by any of the patients.<bold>Conclusion: </bold>64-row CT quantitative perfusion imaging allows head and neck SCC to be distinguished from normal tissues.
- Publication
European Radiology, 2011, Vol 21, Issue 1, p113
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-010-1898-0