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- Title
Laser-induced thermotherapy (LITT)--evaluation of a miniaturised applicator and implementation in a 1.0-T high-field open MRI applying a porcine liver model.
- Authors
Streitparth F; Knobloch G; Balmert D; Chopra S; Rump J; Wonneberger U; Philipp C; Hamm B; Teichgräber U; Streitparth, Florian; Knobloch, Gesine; Balmert, Dirk; Chopra, Sascha; Rump, J; Wonneberger, Uta; Philipp, Carsten; Hamm, Bernd; Teichgräber, Ulf
- Abstract
<bold>Objective: </bold>To evaluate the feasibility and safety of a novel LITT applicator for thermal ablation of liver malignancies in 1.0-T high-field open MRI.<bold>Methods: </bold>A miniaturised 6-F double-tubed protective catheter with a closed cooling circuit was used with a flexible laser fibre, connected to a 1,064-nm Nd:YAG laser and evaluated in non-perfused porcine livers (18-30 W for 10-20 min, 2-W and 2-min increments; n = 210/applicator) in reference to an established 9-F system. As a proof of concept, MR-guided LITT was performed in two healthy domestic pigs in high-field open MRI.<bold>Results: </bold>Ex-vivo, the coagulation volumes induced by the 6-F system with maximum applicable power of 24 W for 20 min (33.0 ± 4.4 cm(3)) did not differ significantly from those set with the 9-F system at 30 W for 20 min (35.8 ± 4.9 cm(3)) (p = 0.73). A flow-rate of 15 ml/min of the cooling saline solution was sufficient. MR navigation and thermometry were feasible.<bold>Conclusion: </bold>The miniaturised 6-F applicator can create comparable coagulation sizes to those of the 9-F system. Applicator guidance and online-thermometry in high-field open MRI are feasible.
- Publication
European Radiology, 2010, Vol 20, Issue 11, p2671
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-010-1831-6