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- Title
Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer.
- Authors
Castelli, Chiara; Rivoltini, Licia; Rini, Francesca; Belli, Filiberto; Testori, Alessandro; Maio, Michele; Mazzaferro, Vincenzo; Coppa, Jorgelina; Srivastava, Pramod K.; Parmiani, Giorgio
- Abstract
Heat shock proteins (HSPs) are a large family of proteins with different molecular weights and different intracellular localizations. These proteins undertake crucial functions in maintaining cell homeostasis, and therefore they have been conserved during evolution. Hsp70 and Grp94/gp96, due to their peptide chaperone capacity and their ability to actively interact with professional antigen-presenting cells (APCs), are also endowed with crucial immunological functions. The immunological properties of these proteins and their implications for vaccine in human cancer will be discussed. Immunological and clinical data of phase I/II studies in melanoma and colorectal cancer patients will be reviewed.
- Subjects
HEAT shock proteins; CANCER patients; VACCINATION; HOMEOSTASIS; MOLECULAR chaperones; PREVENTIVE medicine
- Publication
Cancer Immunology, Immunotherapy, 2004, Vol 53, Issue 3, p227
- ISSN
0340-7004
- Publication type
Article
- DOI
10.1007/s00262-003-0481-9