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- Title
High prevalence of vitamin D deficiency and lack of association with subclinical atherosclerosis in asymptomatic patients with Type 1 Diabetes Mellitus from a Mediterranean area.
- Authors
Serra-Planas, Enric; Aguilera, Eva; Granada, M.; Soldevila, Berta; Salinas, Isabel; Reverter, Jorge; Pizarro, Edu; Pellitero, Silvia; Alonso, Núria; Mauricio, Dídac; Puig-Domingo, Manel
- Abstract
Aims: Several studies linked vitamin D deficiency with coronary artery disease (CAD). The aim of this study was to evaluate the relationship between the concentrations of 25-hydroxyvitamin D (25OHD) and the presence of early atherosclerosis in asymptomatic Type 1 Diabetes (T1D) patients with no previous history of ischemic heart disease. Methods: One hundred and forty-five patients with T1D (age 37.8 ± 8 years, 57 % male, all Caucasian, disease duration 20.6 ± 8.3 years, HbA1c 7.6 ± 1.4 % (60.2 ± 11.1 mmol/mol), body mass index (BMI) 25.2 ± 3.5 kg/m2, 52.4 % smokers, 23 % retinopathy, 10 % nephropathy) and 48 controls matched for age, sex, BMI and smoking habit were studied. 25OHD deficiency was defined for values ≤20 ng/mL. A sun exposure questionnaire, carotid ultrasonography to determine carotid intima-media thickness (CIMT) and the presence of atheroma plaques and cardiac computed tomography for evaluation of calcium artery calcification (CACS) were performed. Results: T1D subjects showed a high proportion of 25OHD deficiency (43.2 % vs. 21.7 %, p = 0.032). Of all, 82 % of T1D patients and 92 % of controls had a calcium score of 0. CIMT was greater in patients with T1D (0.55 ± 0.14 mm vs 0.48 ± 0.15, p = 0.01) compared with controls. T1D subjects showed no differences in the results of CACS or CIMT according to the vitamin D concentrations. Conclusions: T1D patients have lower concentrations and twice more prevalence of 25OHD deficiency than controls. There was no association between 25OHD concentrations and subclinical CAD.
- Subjects
MEDITERRANEAN Region; VITAMIN D deficiency; DISEASE prevalence; ATHEROSCLEROSIS; TYPE 1 diabetes; BODY mass index; DIAGNOSIS; PATIENTS
- Publication
Acta Diabetologica, 2015, Vol 52, Issue 4, p773
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-014-0699-3