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- Title
Incidence and Mechanisms of Resistance to Trimethoprim in Clinically Isolated Gram-Negative Bacteria.
- Authors
Grey, Daphne; Hamilton-Miller, J.M.T.; Brumfitt, W.
- Abstract
Over an 18-month period (October 1973 to April 1975), 133 strains of gram-negative bacteria with acquired resistance to trimethoprim (TM) were isolated from infected urines cultured at the Royal Free Hospital. The overall frequency of resistance was 3.2%. A disproportionately high number of resistant strains (63.1%) were Klebsiella aerogenes. Resistance to TM mediated by R plasmids occurs infrequently (9% of all resistant strains); the majority of TM R plasmids isolated belonged to one incompatability group (W). Chromosomally mediated resistance to TM in most Escherichia coli and K. aerogenes strains appears to be due mainly to production of a dihydrofolate reductase with a reduced susceptibility to TM. In some strains, increased activity of the DHFR was also a contributing factor. Increase in enzyme level alone was only great enough to account for the level of resistance to TM in a small number of cases. Copyright © 1979 S. Karger AG, Basel
- Publication
Chemotherapy (0009-3157), 1979, Vol 25, Issue 3, p147
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000237834