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- Title
Influence of ACE I/D gene polymorphism in the progression of renal failure in autosomal dominant polycystic kidney disease: a meta-analysis.
- Authors
Pereira, Tiago Veiga; Nunes, Ane Cláudia Fernandes; Rudnicki, Martina; Magistroni, Ricardo; Albertazzi, Alberto; Pereira, Alexandre Costa; Krieger, José Eduardo
- Abstract
Background. Autosomal dominant polycystic kidney disease (ADPKD) is a renal disease characterized by an important variability in clinical course, which cannot be fully explained by the genetic heterogeneity of the disease. Although the role for the angiotensin I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism as a modifier factor in ADPKD renal deterioration has been suggested, direct evidence from genetic association studies remain inconclusive. To provide a more robust estimate of the putative effect of the ACE I/D polymorphism on the renal progression in ADPKD, we performed a meta-analysis pooling data from all relevant studies in which the role of the ACE I/D variant in ADPKD clinical features was evaluated.
- Publication
Nephrology Dialysis Transplantation, 2006, Vol 21, Issue 11, p3155
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfl412