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- Title
Microemulsion cyclosporin formulation, in contrast to the old formulation, widens the T lymphocyte subsets differences between stable and acute rejection of kidney transplants.
- Authors
Oliveira, José G. G.; Ramos, João P.; Xavier, Paula; Sampaio, Susana; Magalhães, Maria C.; Mendes, Armando A.; Pestana, Manuel
- Abstract
Background. The new cyclosporin (CsA) formulation, Neoral®, has different pharmacokinetics compared with Sandimmune® (SIM). Larger area under the curve (AUC) values with equivalent trough blood values are reached when Neoral is administered at equivalent doses to SIM. Previously, we showed a great diagnostic reliability when using cytofluorometric analysis from fine‐needle aspiration biopsy (FNAB) samples. We investigated possible changes brought about by Neoral on lymphocyte subsets and the repercussions on the activation score cut‐off for acute rejection, defined under SIM treatment.
- Publication
Nephrology Dialysis Transplantation, 2001, Vol 16, Issue 6, p1256
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/16.6.1256