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- Title
Decrease of caffeine elimination in man during co-administration of 4-quinolones.
- Authors
Stille, Wolfgang; Harder, Sebastian; Mieke, Sylvia; Beer, Christian; Shah, Pramod M.; Frech, Karin; Staib, A. Horst; Stille, W; Harder, S; Mieke, S; Beer, C; Shah, P M; Frech, K; Staib, A H
- Abstract
The single dose pharmacokinetics of caffeine (220-230 mg per dose) were investigated in 12 healthy male volunteers before and during treatment with ofloxacin (200 mg bd), ciprofloxacin (250 mg bd) and enoxacin (400 mg bd) with a cross-over study design. None of the parameters: mean elimination half-life (T1/2el), Cmax, total body clearance (Cltot) and the volume of distribution (aVd) of caffeine were noticeably altered by administration of ofloxacin. Striking changes were observed, however, after administration of enoxacin: the T1/2el was prolonged by as much as 260%, the Cmax increased by 41%; the aVd was reduced by 20% and Cltot by 78% (mean values). Treatment with ciprofloxacin led to a prolongation of T1/2el by 15%, to a decrease of aVd by 25% and to a 33% decrease of Cltot. The results of this intra-individual comparison of caffeine pharmacokinetic data demonstrate that treatment with ciprofloxacin and enoxacin may have a significant inhibitory effect on caffeine elimination.
- Subjects
ANTI-infective agents; CAFFEINE; CIPROFLOXACIN; DRUG interactions; HETEROCYCLIC compounds; HIGH performance liquid chromatography; QUINOLINE; QUINOLONE antibacterial agents; TIME; ENOXACIN; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1987, Vol 20, Issue 5, p729
- ISSN
0305-7453
- Publication type
journal article