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- Title
In-vitro antibacterial activity of L-105, a new cephalosporin.
- Authors
Hikida, M; Inoue, M; Mitsuhashi, S
- Abstract
L-105 (sodium(-)-(6R, 7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyimino- acetamido]-3-[1,2,3-thiadiazol-5-yl)thiomethyl]-8-oxo-5-thia-1-aza bicyclo [4.2.0]oct-2-ene-2-carboxylate) is a new semisynthetic cephalosporin derivative. The in-vitro antibacterial activity of L-105 against clinical isolates of 18 bacterial species was compared with those of cefmenoxime, cefoperazone and cefazolin. Its spectrum against Gram-negative bacteria was similar to that of cefmenoxime. Moreover, against Gram-positive bacteria, including Staphylococcus aureus, coagulase negative staphylococci, Streptococcus faecalis, Str. pneumoniae and Str. pyogenes, L-105 was more potent than cefmenoxime and cefoperazone. Against Gram-positive bacteria, including Staph. aureus which is comparatively resistant to most third-generation cephalosporins, it was nearly equal in potency to cefazolin. L-105 was stable to various penicillinases and cephalosporinases. However, this compound was slightly hydrolyzed by oxyiminocephalosporinases, i.e., the enzymes produced by Pseudomonas cepacia and Ps. maltophilia.
- Subjects
ANTI-infective agents; CEFOPERAZONE; CEFOTAXIME; COMPARATIVE studies; GRAM-negative bacteria; GRAM-positive bacteria; HYDROLASES; RESEARCH methodology; MEDICAL cooperation; MICROBIAL sensitivity tests; RESEARCH; EVALUATION research; CEFAZOLIN; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1986, Vol 18, Issue 4, p585
- ISSN
0305-7453
- Publication type
journal article