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- Title
Identity Elements of tRNA as Derived from Information Analysis.
- Authors
Zamudio, Gabriel S.; José, Marco V.
- Abstract
The decipherment of the tRNA’s operational code, known as the identity problem, requires the location of the sites in the tRNA structure that are involved in their correct recognition by the corresponding aminoacyl-tRNA synthetase. In this work, we determine the identity elements of each tRNA isoacceptor by means of the variation of information measure from information theory. We show that all isoacceptors exhibit sites associated with some bases of the anticodon. These sites form clusters that are scattered along the tRNA structure. The clusters determine the identity elements of each tRNA. We derive a catalogue of clustered sites for each tRNA that expands previously reported elements.
- Subjects
AMINOACYL-tRNA synthetases; GENETIC code; GENETIC transcription; INFORMATION theory; MOLECULAR genetics
- Publication
Origins of Life & Evolution of the Biosphere, 2018, Vol 48, Issue 1, p73
- ISSN
0169-6149
- Publication type
Article
- DOI
10.1007/s11084-017-9541-6