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- Title
Physical mapping of the CXC chemokine locus on human chromosome 4.
- Authors
O’Donovan, N.; Galvin, M.; Morgan, J.G.
- Abstract
A physical map of the CXC chemokine locus on chromosome 4 has been constructed by PCR analysis and PFGE mapping of YAC clones. The genes for IL8, GRO1, PPBP, PF4, SCYB5 (ENA-78) and SCYB6 (GCP-2) have been co-localized on a 335-kb genomic fragment. The GRO2 and GRO3 genes did not map within this region and based on analysis of a YAC contig overlapping IL8 we speculate that GRO2 and GRO3 map downstream of this region. We have also assigned the novel CXC chemokine gene, SCYB9B (alias H174/βR1) to chromosome 4q21, upstream and within 12 kb of INP10. Like INP10 and MIG, INP10 and SCYB9B are arranged in a head to tail manner. The chromosomal arrangement of these genes appears to reflect the evolution of this multigene family and supports the theory that it arose by gene duplication.
- Publication
Cytogenetic & Genome Research, 1999, Vol 84, Issue 1/2, p39
- ISSN
1424-8581
- Publication type
Article
- DOI
10.1159/000015209