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- Title
灵芝子实体多糖对小鼠急性酒精肝损伤预防的代谢组分析.
- Authors
叶丽云; 孟国良; 吴龙月; 郝金斌; 程冰; 傅俊生; 吴小平
- Abstract
Polysaccharide is one of the main pharmacological active components of Ganoderma lingzhi. The preventive effect of polysaccharides from G. lingzhi fruit-body(GLFPS) on acute alcoholic liver injury in mice was analyzed by detecting serum indexes, and the mechanism of metabonomics was explored. The results showed that GLFPS significantly inhibited the levels of ALT, AST, TG, TC and ADH in serum of mice induced by alcohol. With the help of metabonomics analysis, 85 different metabolites were obtained between the model group and the control group. Among them, adenosine triphosphate, L-aspartic acid, and L-lysine play important roles in the interaction network, indicating that alcohol can cause changes in the metabolism of adenosine and amino acids in the liver of mice. There were 58 different metabolites between the GLFPS treated group and the model group, mainly including lipids and organic oxygen. KEGG enrichment analysis of different metabolites showed that they were involved in choline metabolism, glycerophospholipid metabolism, and ABC transporters. GLFPS can effectively relieve hurt of these three metabolic pathways significantly changed by alcohol. In conclusion, GLFPS effectively prevent alcoholic liver injury by regulating the metabolism of choline, glycerophospholipids, and some ABC transporters in mice.
- Subjects
AMINO acid metabolism; ALCOHOLIC liver diseases; ATP-binding cassette transporters; ADENOSINE triphosphate; GLYCEROPHOSPHOLIPIDS; CHOLINE; ALANINE aminotransferase
- Publication
Mycosystema, 2021, Vol 40, Issue 9, p2376
- ISSN
1672-6472
- Publication type
Article
- DOI
10.13346/j.mycosystema.210156