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- Title
Postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductive technologies: a cohort study.
- Authors
Valenzuela‐Alcaraz, B; Serafini, A; Sepulveda‐Martínez, A; Casals, G; Rodríguez‐López, M; Garcia‐Otero, L; Cruz‐Lemini, M; Bijnens, B; Sitges, M; Balasch, J; Gratacós, E; Crispi, F; Valenzuela-Alcaraz, B; Sepulveda-Martínez, A; Rodríguez-López, M; Garcia-Otero, L; Cruz-Lemini, M
- Abstract
<bold>Objective: </bold>To assess the postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductive technologies (ART) in children at 3 years of age.<bold>Design: </bold>A cohort study of children conceived by ART.<bold>Setting: </bold>Maternal-Fetal Medicine Unit, Hospital Clinic Barcelona, Spain.<bold>Population Sample: </bold>Eighty singleton pregnancies conceived by ART and 80 spontaneously conceived (controls) followed from fetal life up to childhood.<bold>Methods: </bold>Cardiovascular evaluation was performed at 3 years of corrected age, including echocardiography, carotid intima-media (cIMT) by ultrasound, and blood pressure.<bold>Main Outcome Measures: </bold>Postnatal persistence of cardiovascular changes in children conceived by ART.<bold>Results: </bold>Compared with controls, children conceived by ART showed larger atria (right atrial area: control 4.9 cm2 (0.9) versus ART 5.5 cm2 (0.9), P < 0.001), more globular ventricles (right ventricular sphericity index: control mean 1.8 (SD 0.5) versus ART 1.6 (0.2), P < 0.001), and signs of systolic (tricuspid annular plane systolic excursion: control 18 mm (2) versus ART 16 mm (3), P < 0.001) and diastolic dysfunction (isovolumic relaxation time: control 68 ms (12) versus ART 79 ms (12), P < 0.001). ART children also presented increased systolic blood pressure (control 90 mmHg (6) versus ART 94 mmHg (5), P < 0.003) and cIMT (control 0.52 μm (0.14) versus ART 0.60 μm (0.16), P < 0.001) as compared with those spontaneously conceived.<bold>Conclusions: </bold>Cardiovascular changes previously reported in ART fetuses persist postnatally at 3 years of age. These results underscore the importance of future studies for assessing the long-term cardiovascular health associated with ART.<bold>Tweetable Abstract: </bold>Cardiovascular changes described in fetuses conceived by ART, persist in children at 3 years of age.
- Subjects
HUMAN reproductive technology; CARDIOVASCULAR diseases; FETAL heart; CARDIAC contraction; HEART ventricles; BLOOD pressure; ECHOCARDIOGRAPHY; LONGITUDINAL method; QUESTIONNAIRES; RESEARCH funding; ULTRASONIC imaging; VENTRICULAR remodeling; CASE-control method; CAROTID intima-media thickness
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2019, Vol 126, Issue 2, p291
- ISSN
1470-0328
- Publication type
journal article
- DOI
10.1111/1471-0528.15246