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- Title
Mecanisme moleculare ale rezistenţei medicamentoase implicate în farmacoterapia cancerului.
- Authors
Nicolae, Alina Crenguța; Trăistaru, Camelia; Arsene, Andreea Letiția; Docea, Anca Oana; Petreanu, Manuela; Udeanu, Denisa Ioana; Drăgoi, Cristina Manuela
- Abstract
Cancer is one of the leading causes of death worldwide. Originally, cancer is a genetic disease. Cancer development is a complex process involving genetic and epigenetic alterations, and the inactivation of tumor suppressor genes, theamplification of DNA sequences, chromosome rearrangements and mutations that cause the activation of oncogenes represent some of the mechanisms by which cancer is developed. Current pharmacotherapy options include cancer surgery, radiotherapy and systemic chemotherapy. The introduction of targeted therapy in medical practice has resulted in limiting the cytotoxic action to normal cells. If the problems related to the specificity of antitumor agents, by modulating their pharmacologic features, can be solved using targeted therapy, the major problem in the treatment of cancer remains the resistance that cancer cells develop on the basis of genetic heterogeneity. The development of multidrug resistance (MDR) mechanisms determines the transformation of chemosensitive cancer cells in chemoresistant cells, which may lead to the failure of therapy.
- Subjects
CANCER-related mortality; GENETIC disorders; TUMOR growth; CHROMOSOMAL rearrangement; CHROMOSOME abnormalities; RADIOTHERAPY; CANCER chemotherapy
- Publication
Farmacist.ro, 2017, Issue 6, p15
- ISSN
1584-6539
- Publication type
Article