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- Title
Breastfeeding and the Risk of Ovarian Cancer: A Meta-Analysis.
- Authors
Feng, Li-Ping; Chen, Hong-Lin; Shen, Mei-Yun
- Abstract
Introduction The aim of this meta-analysis was to assess the association between breastfeeding and risk of ovarian cancer. Methods Relevant observational studies were identified by a search of the MEDLINE and EMBASE databases through December 2012. Summary odds ratios (ORs) for ovarian cancer, comparing women who had breastfed with women who had not, were calculated using a random-effects model. A dose-response meta-analysis assessed the risk of ovarian cancer by breastfeeding duration. Results A total of 19 studies were included in the meta-analysis. Compared with women who had not breastfed, women who had breastfed had a significantly decreased risk of ovarian cancer, with an OR of 0.66 (95% CI, 0.57-0.76; P < .001). We observed an inverse linear relationship with breastfeeding duration: for every one-month increase in breastfeeding, the OR was 0.98 (95% CI, 0.97-0.99; P < .001). A nonlinear association was also apparent, with a sharp decrease in the OR when breastfeeding duration was 8 to 10 months. There was evidence of heterogeneity ( I2 = 83.9%). No publication bias was found (Begg test, P = 0.89; Egger test, P = 0.89). Discussion Breastfeeding reduces the risk of ovarian cancer proportional to duration. Breastfeeding for 8 to 10 months may be most effective for reducing the risk of ovarian cancer.
- Subjects
OVARIAN tumors; BREASTFEEDING; CONFIDENCE intervals; DOSE-response relationship in biochemistry; META-analysis; PROBABILITY theory; REGRESSION analysis; STATISTICS; DATA analysis; DATA analysis software; DESCRIPTIVE statistics; ODDS ratio; TUMOR risk factors
- Publication
Journal of Midwifery & Women's Health, 2014, Vol 59, Issue 4, p428
- ISSN
1526-9523
- Publication type
Journal Article
- DOI
10.1111/jmwh.12085