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- Title
Vitamin D Insufficiency and Abnormal Hemoglobin A1c in Black and White Older Persons.
- Authors
Kositsawat, Jatupol; Kuchel, George A.; Tooze, Janet A.; Houston, Denise K.; Cauley, Jane A.; Kritchevsky, Stephen B.; Strotmeyer, Elsa S.; Kanaya, Alka M.; Harris, Tamara B.; Johnson, Karen C.; Barry, Lisa C.
- Abstract
Background. Although vitamin D has been mechanistically linked to insulin secretion and sensitivity, it remains unclear whether low 25-hydroxyvitamin D levels confer an increased risk of impaired glucose metabolism. We evaluated the relationship between vitamin D insufficiency (25-hydroxyvitamin D < 20ng/mL) and abnormal hemoglobin A1c (A1c) (>6.5%) in community-dwelling older persons and examined whether this relationship differed according to race. Methods. Participants were 2,193 persons of age 70-79 years at Year 1 (52% women; 37% black) in the Health, Aging, and Body Composition study who had clinic visits at Years 2 and 4. Logistic regression analyses, adjusted for potential confounders, were used to evaluate the association between vitamin D insufficiency and abnormal A1c 2 years later. Interaction of race and vitamin D insufficiency was tested. Results. A total of 665 (30%) and 301 (14%) of the participants had vitamin D insufficiency at Year 2 and abnormal A1c at Year 4, respectively. After controlling for demographics, other potential confounders, and diabetes status at Year 4 (n = 477 diabetics), we found that vitamin D insufficiency was associated with an increased likelihood of having abnormal A1c (odds ratio = 1.56; 95% CI: 1.03-2.37). We also found that this relationship persisted among the 1,765 participants without diabetes in Year 2 (odds ratio = 2.33 ; 95% CI: 1.00-5.40). Findings did not differ by race. Conclusions. Vitamin D insufficiency was associated with abnormal A1c levels among black and white older persons independent of diabetes status. Future studies are needed to establish the temporal relationship between vitamin D and A1c in diverse samples of older persons.
- Subjects
UNITED States; VITAMIN D; INSULIN research; GLUCOSE metabolism; HEMOGLOBINS; DIABETES; METABOLIC syndrome; OLDER people
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2015, Vol 70, Issue 4, p525
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/glu122