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- Title
Conserved Noncoding Sequences Highlight Shared Components of Regulatory Networks in Dicotyledonous Plants.
- Authors
Baxter, Laura; Jironkin, Aleksey; Hickman, Richard; Moore, Jay; Barrington, Christopher; Krusche, Peter; Dyer, Nigel P.; Buchanan-Wollaston, Vicky; Tiskin, Alexander; Beynon, Jim; Denby, Katherine; Ott, Sascha
- Abstract
Conserved noncoding sequences (CNSs) in DNA are reliable pointers to regulatory elements controlling gene expression. Using a comparative genomics approach with four dicotyledonous plant species (Arabidopsis thaliana , papaya [ Carica papaya ], poplar [ Populus trichocarpa ], and grape [ Vitis vinifera ]), we detected hundreds of CNSs upstream of Arabidopsis genes. Distinct positioning, length, and enrichment for transcription factor binding sites suggest these CNSs play a functional role in transcriptional regulation. The enrichment of transcription factors within the set of genes associated with CNS is consistent with the hypothesis that together they form part of a conserved transcriptional network whose function is to regulate other transcription factors and control development. We identified a set of promoters where regulatory mechanisms are likely to be shared between the model organism Arabidopsis and other dicots, providing areas of focus for further research.
- Subjects
GENE regulatory networks; TRANSCRIPTION factors; GENE expression; BINDING sites; PAPAYA; BLACK cottonwood; VITIS vinifera
- Publication
Plant Cell, 2012, Vol 24, Issue 10, p3949
- ISSN
1040-4651
- Publication type
Article
- DOI
10.1105/tpc.112.103010