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- Title
Synthesis and Biological Activity of 3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4- c]pyrazol-6(2 H)-ones and Their Sodium Salts.
- Authors
Bobrovskaya, O.; Gein, V.; Seliverstov, G.; Chashchina, S.; Dmitriev, M.
- Abstract
3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4- c]pyrazol-6(2 H)-ones were synthesized be reaction of 5-aryl-4-aroyl-1-[4-(acetylsulfamoyl)phenyl]-3-hydroxy-1 H-pyrrole-2(5 H)-ones with hydrazine hydrate in glacial acetic acid, and their sodium salts were obtained by treatment with sodium methoxide in methanol-DMF (1: 1). Analgesic and anti-inflammatory activity and acute toxicity of the synthesized compounds were studied.
- Subjects
SODIUM salts; ACETYL compounds; ANALGESICS; PYRAZOLES; HETEROCYCLIC compounds synthesis; PYRAZOLE derivatives; ANALGESIC synthesis
- Publication
Russian Journal of General Chemistry, 2017, Vol 87, Issue 12, p2776
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363217120040