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- Title
A glioblastoma arising from the attached region where a meningioma had been totally removed.
- Authors
Ohba, Shigeo; Shimizu, Kazuhiko; Shibao, Syunsuke; Miwa, Tomoru; Nakagawa, Toru; Sasaki, Hikaru; Murakami, Hideki
- Abstract
The co-occurrence of different histological tumors in the nervous system is rare and is mainly associated with phakomatoses or radiation exposure. A 72-year-old man underwent surgery for a frontal convexity meningioma. Four years after the surgery, a new lesion was detected in the attached region where the meningioma had been removed. The second tumor exhibited a high degree of cellularity, atypical mitosis, pseudo-palisading and microvascular proliferation, and was immunohistologically positive for GFAP and was diagnosed as a glioblastoma. Wild-type isocitrate dehydrogenase 1 was found in the second specimen. A genetic analysis using comparative genomic hybridization showed a DNA copy number loss on 1p35, 9pter-21, 10, 11q23, 13q, 14q, 20q, 22q and a gain on 7 in the second specimen. Although the mechanism responsible for the consecutive occurrence of meningioma and glioblastoma has not been elucidated, five hypotheses are feasible: (i) the lesions occurred incidentally; (ii) a low-grade astrocytoma present at the time of the first operation transformed into a high-grade glioma during the next 4 years; (iii) radiation received during the endovascular treatment induced glioblastoma; (iv) a brain scar created at the time of the first operation for meningioma led to the occurrence of a glioblastoma; and (v) the previous meningioma affected the surrounding glial cells, causing neoplastic transformation.
- Subjects
CASE studies; MENINGIOMA; BRAIN tumors; COMPARATIVE genomic hybridization; GLIOMAS; ASTROCYTOMAS; POSTOPERATIVE care
- Publication
Neuropathology, 2011, Vol 31, Issue 6, p606
- ISSN
0919-6544
- Publication type
Article
- DOI
10.1111/j.1440-1789.2011.01198.x